How a small number of risky experiments creates many unwieldy problems for life science research.The life sciences have never been more critical to human health, wealth, and security. But with any endeavor comes risk, and the last decade has seen concerns raised about gain-of function-research in which a microbe, usually a virus, is given new properties like enhanced lethality, transmissibility, or the capability to infect new species. In 2021 the term seeped into the tabloids when a conflict between Senator Rand Paul and Dr. Anthony Fauci arose over the origins of COVID-19. In Gain of Function, Nicholas Evans—who has spent his career studying gain-of-function research—describes what this kind of research is, what it isn’t, and why a small number of scientific experiments continues to make headlines.Evans begins with a description of what gain-of-function research is in science, and what it means in government policy. He tells the story of the original papers that sparked controversy more than a decade ago, unpacking them for readers unfamiliar with virology research, and he identifies where and why policymakers and scientists alike became concerned. He then turns to the history of policies that attempt to regulate gain-of-function research, the current controversies, and the ethics of risky research. He concludes with the future of gain of function, including how debates about gain of function will influence science and public health in years to come.New pathogen research rules: Gain of function, loss of clarity “Gain-of-function” experiments were defined by the US government as experiments that resulted in the creation of pathogens with enhanced . Neurodegenerative Disorders: Loss of Function Through Gain of . The book provides insights into the cellular and animal models of these diseases, and how the molecular basis of neurodegeneration has become the preferred . Trump restricts funding for 'gain-of-function' research - KPBS But gain-of-function research became especially controversial and politically polarized during the COVID-19 pandemic. One theory for how the . The Gain-of-Function Deliberative Process (Carrie Wolinetz) - Scribd The document discusses the US government's deliberative process around gain-of-function (GOF) research. It notes that while some GOF studies could provide . Trump & RFK Jr ban US funding for Gain-of-Function . - YouTube On Monday, President Trump signed an executive order limiting federal funding for research in a controversial area known as . Trump restricts funding for 'gain-of-function' research - Maine Public But gain-of-function research became especially controversial and politically polarized during the COVID-19 pandemic. One theory for how the . Gain-of-function research advances knowledge and saves lives | STAT Gain-of-function research has uncovered foundational knowledge about biology. It also helped create one of the authorized Covid-19 vaccines. International community 'complicit' in gain-of-function research: book The National Institutes of Health (NIH) came under fire this week after it admitted to funding gain-of-function research on the coronavirus . Trump freezes 'gain of function' pathogen research - Nature An executive order suspends the use of federal funds for certain experiments on pathogens with pandemic potential. Expert Roundtable: Gain of Function Research With Infectious Agents One-pager discussing gain of function research with infectious agents including an overview and recommendations. Gain-of-function research and the origins of Omicron | InSight+ “The same technology can also be used to harm humanity. So, gain-of-function research is where you engineer a pathogen to confer on it . Potential risks and benefits of gain-of-function research "On October 17, 2014, spurred by incidents at U.S. government laboratories that raised serious biosafety concerns, the United States government launched a . S. 738: Dangerous Viral Gain of Function Research Moratorium Act 738: Dangerous Viral Gain of Function Research Moratorium Act. Track S . Blue Book; Wikipedia Template. Where is this information from . Pandemic Roulette: Risks and Rewards of Virological Gain-of . Gain-of-function research, which adds or modifies properties to an existing organism or virus, can sometimes lead scientists to create new pathogens that are . Gain of Function a book by Nicholas G. Evans - Bookshop.org US Evans begins with a description of what gain-of-function research is in science, and what it means in government policy. He tells the story of the original .